We love seeing the history of PASC. Thank you so much, @Kristie Leary, for sending us this great video of your grandparents, Michael Leary and Gloria (Myers) Leary, and your great-aunt, Patricia McGilvray. This was filmed in 1939/1940 and shows one of the early PASC Salmon Derbys. Kristy says, "And yes, it’s odd, but the film was originally in color (I didn’t edit it). It was rare for folks to have color film/processing back then, but I also have their wedding from Port Angeles on film from 1940

How does sars-cov-2 virus promote synaptic damage and cognitive impairments in patients with postacute sequelae of SARS-CoV-2 infection (PASC)? --Pathologic mechanism: Patients with postacute sequelae of SARS-CoV-2 infection (PASC)->🔽 PGC-1α-> 🔼synaptic pruning-> 🔼synaptic damage and cognitive impairments--Therapeutic mechanism: Patients with postacute sequelae of SARS-CoV-2 infection (PASC) + p53/NRF2-based therapy-> 🔼 PGC-1α-> 🔽synaptic pruning-> 🔽synaptic damage and cognitive impairment