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6:39
GSK2118436 (dabrafenib) with and without the oral MEK1/2 inhibitor GSK1120212 (trametinib)
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Today we announced positive Phase 2 results from our ongoing TUPELO trial evaluating REC-4881 in patients with familial adenomatous polyposis (FAP) – a rare, inherited disease with no approved pharmacologic treatments. Treatment with REC-4881 demonstrated rapid and durable reductions in polyp burden in the study, with a median 43% reduction in total polyp burden (n=12) after 12 weeks of treatment. 82% of evaluable patients (9 of 11) maintained reductions at Week 25—12 weeks after stopping therap
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