HIV fusion and entry are two steps in the viral lifecycle that can be targeted by several classes of antiviral drugs. The discovery of chemokines focused the attention on cellular co-receptors used by ...

A new study overthrows a long-held theory on how HIV finds its way into host cells. Rather than fusing directly with the host cell membrane, the virus is first engulfed by it to form a vesicle that ...

Scientists may need to rethink the design of drugs meant to block HIV from infecting human cells, according to a new study. That's because the new report shows that HIV doesn't enter cells in the way ...

HIV-1 remodels the spatial organization of its co-receptor, CXCR4, on T cell membranes, showing that viral entry requires receptor clustering rather than simple receptor binding.

As enemies go, the human immunodeficiency virus has proven particularly shrewd at evading attempts to defeat it. Decades into the fight against HIV, statistics on the virus’s toll are still staggering ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

At the cellular level, HIV-1 transmission involves a highly coordinated process whereby the virus binds to CD4 receptors and one of two coreceptors—CCR5 (R5) or CXCR4 (X4)—on host immune cells, ...

“There have been as many plagues as wars in history; yet always plagues and wars take people equally by surprise.” ― Albert Camus, The Plague As the world strives to find a cure for the ongoing ...

HIV infects immune cells by first using its surface glycoprotein to engage with a cell surface receptor and a coreceptor in a three-way embrace. Long-standing efforts to structurally analyze this ...