Assembly of HIV-1, which causes AIDS, takes place on the inner plasma membrane leaflet of infected cells, a geometric building process that creates hexamers out of trimers of the viral Gag protein, as ...
Assembly of HIV-1, which causes AIDS, takes place on the inner plasma membrane leaflet of infected cells, a geometric building process that creates hexamers out of trimers of the viral Gag protein, as ...
Since HIV’s discovery in the 1980s, scientists have come a long way in understanding the different steps required for its assembly and maturation. Researchers knew, for instance, that HIV wraps its ...
But in the case of fighting AIDS, HIV's ability to rapidly mutate, especially its outer coat protein -- the envelope -- poses a special challenge to vaccine development. So too does the fact that the ...
Jamil Saad, Ph.D. Jamil Saad, Ph.D., professor in the Department of Microbiology, is the latest winner of the Heersink School of Medicine’s Featured Discovery. This initiative celebrates important ...
An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date have suggested the need to increase the durability and functionality of ...
bZIP60-s results from alternative splicing of bZIP60-u by Ire1 due to consumption of BiP by unfolded proteins and is the master transcription factor that upon trafficking to the nucleus induces ...
HIV vaccine efforts have been slowed by the difficulty of getting neutralizing antibodies to target the correct locations of the diverse variants of HIV. Neutralizing antibodies are proteins produced ...
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