To establish factors linked to responses to radiotherapy or chemotherapy is currently a major goal of basic and translational research. It may help select patients for specific treatment and point to ...
The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53 gene alters its response pathway, and is central to the development of many cancers. The discovery of a ...
Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...
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